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Diethylstilbestrol (DES) has only one primary use: the treatment of sphincter tone incontinence in female dogs. DES is used at extremely low doses thus avoiding any toxicity。

DES has been used to treat estrogen responsive tumors, hyperplasia of the prostate gland and in perianal gland adenomas. Howeverdiethylstilbestrol for dogs side effects, neutering (castration) is the initial。

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